Below are the different natural components of Zumma and the evidence behind:

 

L-Arginine

  • One study shows that a significant proportion of erectile dysfunction patients have low l-Arg or l-Cit level and that this condition is more frequent in patients with arteriogenic etiology. Low levels of these nitric oxide synthase substrates might increase the erectile dysfunction risk by reducing the concentration of nitric oxide. (1)
  • Anti-aging study of l-arginine shows that l-Arginine is one of the most metabolically versatile amino acids. In addition to its role in the synthesis of nitric oxide, l-arginine serves as a precursor for the synthesis of polyamines, proline, glutamate, creatine, agmatine and urea. Several human and experimental animal studies have indicated that exogenous l-arginine intake has multiple beneficial pharmacological effects when taken in doses larger than normal dietary consumption. Such effects include reduction in the risk of vascular and heart diseases, reduction in erectile dysfunction, improvement in immune response and inhibition of gastric hyperacidity. These shows that the demonstrated anti-aging benefits of l-arginine show greater potential than any pharmaceutical or nutraceutical agent ever previously discovered.  (2)

Dioscorea villosa aka Wild Yam Extract

  • Dioscorea is a yam steroid extract used in commercial steroid synthesis and consumed by people. DHEA is a steroid which declines with age, but without known activity. This study was designed to determine whether dioscorea supplementation could increase serum dehydroepiandrosterone sulfate (DHEAS) in humans and modulate lipid levels in older people. The subjects were selected volunteers aged 65-82 years. The serum DHEAS level, lipid peroxidation and lipid profile were assessed. Three weeks of dioscorea supplementation had no affect on serum DHEAS level. However DHEA intake of 85 mg/day increased serum DHEA levels 100.3%. DHEA and dioscorea significantly reduced serum lipid peroxidation, lowered serum triglycerides, phospholipid and increased HDL levels. Both DHEA and the steroid yam extract, dioscorea, have significant activities as antioxidant to modify serum lipid levels. (3)

Lycium barbarum Extract aka Goji

  • In an animal study, treatments with goji extracts increased serum testosterone level, increased the expression of endothelial NO synthase, neuronal NO synthase, and cGMP, improved the oxidative stress marker, and decreased corporal fibrosis. Results indicate that goji extract may have a positive effect on erectile dysfunction via its antioxidant effects. (4)
  • In one study, apart from protecting the DNA and alleviating the reproductive tissue damage due to hypothermia, oxidative stress, and radiation, the fruit also protects testis from damage by environment pollutant like BPA. (5)

Cistanche Deserticola Extract

  • In an animal study, it was evaluated that the erectile latency became longer and the erectile duration shorter significantly in castrated rats compared to sham operated controls. However, CD extract shortened the erectile latency and prolonged the erectile duration to minimize the negative effects of castration. (6)
  • In a study to determine how intake of cistanche tubulosa affects the sex hormones, rats were given different quantities of C tubulosa extract for 20 days. The study found that the active ingredients in cistanche stimulated the release of testicular enzymes which caused an increase in progesterone and testosterone levels. The study also found that the herbal extract caused an increase in the amount of sperm and their motility, while amounts of abnormal sperm decreased. This study suggests that intake of cistanche by a man with low testosterone levels can lead to increased T levels. (7)
  • Another study was conducted with the aim of determining whether cistanche tubulosa has protective properties against sperm and testicular poisoning. Male rats were exposed to BPA poisoning and cistanche and echinacoside (an active ingredient of cistanche) for 42 days. Ordinarily BPA causes abnormalities in sperms and testicular structure. However, at the end of this period, tests carried out on the rats showed that cistanche and echinacoside provided protection against BPA poisoning such that these parts of the anatomy of the rats in the study were normal. The study concluded that cistanche and echinacoside provided protection against toxicity. (8)
  • One animal study found that cistanche reduces tension in blood vessels, thereby increasing the flow of blood to areas where it is required. The study also found that cistanche increased production of nitric oxide which helps relax blood vessel walls and thereby ease blood flow. (9)
  • Another animal study found that the rats which were given cistanche extract for 14 days, had better stamina such that they could swim harder and longer than the control group which was not given the herb extract. Cistanche lowers lactic acid levels in muscles and increases blood flow. And by increasing supply of blood, it helps transport nutrients and oxygen within the blood to the brain, muscles and all organs in the body. (10)

Epimedium Extract aka Horny Goat Weed

  • An animal model consisting of aged rats has confirmed that horny goat weed extract can significantly improve erectile function, increase the frequency of intercourses, and decrease the latent period of ejaculation. (11)
  • In a study on human cells in vitro showed that icariin increases the production of nitric oxide (NO) in the endothelium (the cells that line the interior surface of blood vessels). (12)
  • One study confirmed that icariin shows powerful inhibitory effects on human phosphodiesterase-5 (exactly like Viagra), but without any toxicity on fibroblasts (connective tissue cells). (13)
  • Another  study affirmed once more that icariin directly stimulates the formation of new blood vessels, a feat which could be exceptionally beneficial for professional athletes and bodybuilders. (14)

 

REFERENCES:

  1.  Andrology Volume 5, Issue 2 March 2017 Pages 256–261.
  2.  Journal of Advanced Research Volume 1, Issue 3, July 2010, Pages 169-177.
  3.  Life Sci. 1996;59(11):PL147-57.
  4.  World J Mens Health 2017 April 35(1): 43-50.
  5.  Lycium Barbarum and Human Health pp 113-123.
  6.  Pak J Pharm Sci. 2016 Mar;29(2):557-62.
  7.  Pharm Biol. 2016;54(3):481-7.
  8.  Journal of Ethnopharmacology Volume 193, 4 December 2016, Pages 321-328
  9.  Bioorg Med Chem. 2006 Nov 15;14(22):7468-75.
  10.  Phytotherapy Research Volume 24, Issue 2 February 2010 Pages 313–315
  11.  J Ethnopharmacol. 2007 Dec 3;114(3):412-6. Epub 2007 Aug 19.
  12.  Vascul Pharmacol. 2007 Jul;47(1):18-24. Epub 2007 Mar 24.
  13.  J Nat Prod. 2008 Sep;71(9):1513-7.
  14.  Biochem Biophys Res Commun. 2008 Nov 14;376(2):404-8.